Toxic Thermolabile Proteins in the Study of Protein Quality Control
نویسندگان
چکیده
SulA is a division inhibitor of Escherichia coli with a short half life, whose accumulation results in filamentation. Here we show that SulA is thermally unstable and goes into aggregates at elevated temperatures. This property enables the selection of mutants in the protein quality control system.
منابع مشابه
Potential use of toxic thermolabile proteins to study protein quality control systems.
SulA is an Escherichia coli division inhibitor with a short half-life whose accumulation results in filamentation. Here, we show that SulA is thermally unstable and forms aggregates at elevated temperatures. This property enables the selection of isolates with mutated protein quality control systems.
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